= 0. population. Of all women, 30.7% were overweight and 8.1%

= 0. population. Of all women, 30.7% were overweight and 8.1% were obese. Also, 89.9% of women were of Caucasian descent and 10.1% were from black or minority ethnic origin (BME). The largest BME group was of North African descent (3.9% of all women). Of all women, 16.6% were multiparous and 38.3% were primigravid. Using the Carpenter and Coustan criteria, 222 women had GDM (aged GDM group). Using the IADPSG criteria, 382 had GDM of which 160 had an NGT with the aged criteria (new GDM group). Women from the new GDM group were significantly younger (31.6 4.7 versus 33.3 7.2 years, = 0.010) and had a similar BMI (23.3 3.7?kg/m2 versus 24.1 4.5?kg/m2, = 0.281) other than the old GDM group. Both the new GDM and aged GDM groups were GCSF significantly more often from a BME origin (17.4% and 19.7% versus 9.5%, < 0.001) and more often multiparous (25.5% and 20.6% versus 16.3%; only significantly different for buy 131060-14-5 the new GDM group) than the NGT group (Table 1). Table 1 Differences in clinical characteristics between the new GDM group, the aged GDM group, and NGT group. All oral glucose tolerance assessments results were significantly higher in the new GDM group than in the NGT group and were significantly lower than in the aged GDM group (Table 2). Mean Hba1c at diagnosis in the aged GDM group was 37?mmol/mol (5.5% 0.5%). At diagnosis of GDM by the Carpenter and Coustan criteria, 4.2% of women had a mean Hba1c 48?mmol/mol (6.5%). Table 2 Differences in oral glucose tolerance tests results between the new GDM group, the aged GDM group, and NGT group. There were no significant in-between group (new GDM, aged GDM and NGT) differences in the rate of gestational hypertension, preeclampsia, preterm delivery, abnormal Apgar scores, and admission around the NICU (Table 3). These results were not different when adjusted for confounding factors such as maternal age, parity, and ethnicity. The rate of IUGR was low and not significantly different between the groups (0.4% in the new GDM group, 0.5% in the old GDM group, and 1.9% in the NGT group). The rate of delivery by caesarean section was similarly high in the new GDM group as in the aged GDM group (30.5% versus 32.4%; = 0.706), and it was significantly higher than in the NGT group (23.3%, = 0.001). Maternal age (< 0.001) and the rate of women from a BME (= 0.029) origin were significant predictors of the lower rate of delivery by caesarean section in the NGT group compared to the new GDM group. Mean birth weight was not significantly different between the three groups (3278.4 663.3?g in the new GDM group, 3306.7 622.1?g in the aged GDM group, and 3310.9 596.3?g in the NGT group). The rate of macrosomia was also not significantly different between the three groups: 8.5% in the new GDM group, 10.1% in the old GDM group, and 9.1% in NGT group. The rate of LGA was only significantly higher in the aged GDM group compared to the NGT group (10.8% in the new GDM group, 13.8% in the old GDM group, and 9.0% in NGT group). The rate of shoulder dystocia was similarly high in the new GDM group (3.9%) as in the buy 131060-14-5 old GDM group (3.2%, = 0.736), and this was significantly higher than in the NGT group (1.4%, = 0.007). Moreover 36.1% of women with GDM diagnosed by the IADPSG criteria had an FPG meeting the threshold for GDM. Hence, 28.0% (45) of the new GDM group had an elevated FPG. The rate of buy 131060-14-5 shoulder dystocia remained significantly higher compared to the NGT group when only the subgroup of the new GDM group with elevated FPG was used for analyses (< 0.001). These results were also not different when adjusted for confounding factors such as maternal age, parity, and ethnicity. Besides a higher rate of BME origin in the new GDM group with an elevated FPG (56.3% versus 10.9%, = 0.004), characteristics and pregnancy outcomes were the same as the other patients in the new GDM group. Table 3 Differences in pregnancy outcomes between the new GDM group, the aged GDM group, and NGT group. 4. Discussion The IADPSG criteria identified 160 new cases as GDM, previously considered as normal using the Carpenter and Coustan.

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